The therapeutic alliance and its relevance in psychedelic assisted psychotherapy

Alan Jaffe, the author of this viewpoint article writes: "In all forms of psychotherapy, the quality of the therapeutic alliance, which is the quality of the human connection, plays a crucial role in facilitating the effectiveness of the process. In psychedelic therapy, this is especially true as patients are in a highly open, vulnerable, and suggestible state. In psychedelic-assisted therapy, the therapeutic container is built upon alliance, trust, safety, and support. The history of the therapeutic alliance is reviewed and applied to the work of psychedelic psychotherapy."

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Efficacy and safety of a 4-week course of repeated subcutaneous ketamine injections for treatment-resistant depression (KADS study): randomised double-blind active-controlled trial