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UP-TO-DATE, RESEARCH BASED INFORMATION ABOUT PSYCHEDELICS.

Emerging Research Emerging Research

US surge in microdosing interest

Searches for microdosing in the US remained stable until 2014, then increased annually thereafter, with a cumulative increase by a factor of 13.4 from 2015 to 2023 (7.9 per 10 million to 105.6 per 10 million searches, respectively). In 2023, there were 3.0 million microdosing searches in the US.

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Phase 1, placebo-controlled, single ascending dose trial to evaluate the safety, pharmacokinetics and effect on altered states of consciousness of intranasal BPL-003 (5-methoxy-N,N-dimethyltryptamine benzoate) in healthy participants

The intensity of the SDI ratings was associated with plasma 5-MeO-DMT concentrations. MEQ-30 and EDI scores generally increased with the BPL-003 dose; 60% of participants had a ‘complete mystical experience’ at 10 and 12 mg doses.

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At-home, telehealth-supported ketamine treatment for depression: Findings from longitudinal, machine learning and symptom network analysis of real-world data

Conclusions At-home, telehealth-supported ketamine administration was largely safe, well-tolerated, and associated with improvement in patients with depression. Strategies for combining psychedelic-oriented therapies with rigorous telehealth models, as explored here, may uniquely address barriers to mental health treatment.

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Psilocybin mushroom potency can degrade by nearly 50% in six months, new data shows

Tomás says the Hyphae Labs team is designing a more detailed experiment around the longevity of alkaloid molecules, specifically psilocybin and psilocin. The results of the first experiment—and the public’s receptivity to it—warrant a deeper investigation into storage conditions, including how heat, moisture, and oxygen play a role in the degradation of psilocybin and the timeline in which it occurs. Praise the deep-space mushroom deities that someone is doing this work.

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Psychological effects of psychedelics in adolescents

To our knowledge, this is the first prospective study to examine the psychological effects of psychedelic use specifically in adolescents. Statistically significant improvements in psychological well-being and other domains of mental health were observed, consistent with effects seen previously in adults, providing tentative evidence for the potential utility of psychedelic interventions in adolescents.

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