Perceptions of health outcomes following psychedelic use were broadly positive, and psilocybin was reported to be the most effective substance for both physical and mental health symptoms.

We asked Tommaso why he’s so excited about short-acting psychedelics (5-MeO-DMT), how his research into psychedelics and sexual function took off, and what open questions he’d most like to study next.

A first-ever clinical trial of MDMA-assisted therapy for active-duty service members with PTSD.

This revealed that participants consuming psychedelics for spiritual or self-healing purposes reported more intense, while those motivated by curiosity reported less intense ego dissolution experiences.

The authors outline important gaps in our knowledge around the safety and risk profile of psychedelic medicines and identify practical steps forward for researchers and clinical practitioners to make this promising field safer.

The come-up is more often characterized by negatively valenced feeling states that resemble an acute stress reaction, while the come-down phase is more often characterized by positively valenced feeling states of the sort often observed following recovery from illness or resolution of stress.

Psilocybin assisted psychotherapy for methamphetamine use disorder was feasible to implement in an outpatient setting, did not appear to generate safety concerns, and demonstrated signals of effectiveness warranting further investigation.

We only added 11 (January) studies to the database. More studies than ever are reviews, commentaries, and perspectives. Though they can provide a great introduction for a specific audience.

Confidence in negative self-beliefs decreased following 25 mg psilocybin. Entropy and subjective effects under 25 mg psilocybin correlated with decreases in negative self-belief confidence (acutely and at 4-weeks). Particularly strong evidence was seen for a relationship between decreases in negative self-belief confidence and increases in well-being.

The hallucinogenic compound 5-MeO-DMT comes from the secretions of Bufo alvarius, also known as the Sonoran Desert toad. This week, two companies developing synthetic forms of the substance as medical treatments announced preliminary results.

This study describes Oregon’s early psilocybin facilitator workforce and assesses state-approved training programs.

The origins of the ancient Greek Eleusinian Mysteries are lost to time. We know that from the classical period onward, on a specified day in the third month of the Attic calendar (roughly September or October), initiates would walk the fourteen miles from Athens to the town of Eleusis along the “Sacred Road” to celebrate the Greater Mysteries.

Panorama is the second Phase 3 trial of lysergide D-tartrate (LSD) with the primary endpoint measuring the change from baseline in the Hamilton Anxiety Rating Scale (HAM-A) score at week 12 for MM120 Orally Disintegrating Tablet (ODT) 100 µg vs placebo.

This overview seeks to map out drug discovery & development activity in psychedelics. Candidates currently undergoing clinical trials are presented first, while those that are at the discovery or preclinical stage are catalogued in the latter half of this page.

The US FDA has approved a supplemental new drug application allowing esketamine nasal spray to be used as a standalone treatment in adults with major depressive disorder who have not responded adequately to at least two oral antidepressants.

The January edition of the American Journal of Bioethics focuses just on psychedelics. There are a couple of editorials and then four 'target articles' with a further twenty six article commentaries.

Group psilocybin-assisted therapy plus MBSR was associated with clinically significant improvement in depressive symptoms without serious adverse events and with greater reduction in symptoms than MBSR alone.

The body of IFS literature is extensive, enthusiastic, and thought-provoking. Outcome data for applying the model to Post-Traumatic Stress Disorder are limited.

The aim of this study was to explore the psychological and spiritual dimensions of psychedelic integration among mental health professionals, focusing on understanding how transformation and insights influence their clinical work. 

Taken together, these findings suggest that psilocybin therapy may be potentially acceptable and may feasibly help in supporting survivors of adverse childhood experiences with particularly strong benefits to those with more severe childhood adversity.