A comprehensive review of potential uses of ayahuasca in psychiatry

This free full text paper in the Journal of Psychedelic Psychiatry comments: "Objective: This paper aims to provide a review of primarily the human studies of the use of ayahuasca for psychiatric illness and outline the pharmacology and effects of ayahuasca.  Method: Literature review.  Discussion: Ayahuasca has a unique delivery method and mechanism of action involving serotonin and sigma-1 receptors with downstream effects on dopamine and glutamate.  There have been positive studies for using ayahuasca in psychiatric disorders.  However, more extensive clinical trials and safety profiling are required before use in clinical practice."

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